Monitor the patient and obtain serial theophylline concentrations every 2 to 4 hours to determine the effectiveness of therapy and to determine further treatment decisions. Administer multiple-dose, oral-activated charcoal and measures to control emesis. Stop the infusion, monitor the patient, and obtain a serum theophylline concentration in 2 to 4 hours to ensure that the concentration is decreasing.Īcute overdose with a serum concentration of 30 to 100 mcg/mL or chronic overdose with serum concentrations greater than 30 mcg/mL in patients less than 60 years of age:
Manufacturer’s Specific Recommendations for Acute and Chronic OverdoseĪcute overdose (e.g., excessive loading dose or excessive infusion rate for less than 24 hours) or chronic overdose (e.g., excessive infusion rate for more than 24 hours): Serum concentration 20 to 30 mcg/mL:
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